From what I've seen, the 4-2-5 is "new" enough that this depends on both the coverage called and the coach's personal preference.
Here's an example of football-defenses.com's 4-2-5 Cover 3 versus Trips:
But I've seen other sources that leave the Weak Safety on the weak side. Can't find a good example of a "rule" for Man Coverage though.
I believe that the Man Align you speak of is there, and is used by default, but that it's now influenced by the formations. It's no longer a hard and fast adjustment. Some formations/coverages have the LBs or CBs adjust and directly line over the man they're assigned, others don't. I haven't figured out the rhyme or reason yet though.
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