I switched to these in my offline dynasty lasst night and played 3 games, all with good results. Changes from our current settings in Bold

Game Play Sliders: User/CPU
QB Accuracy: 15/10
Pass Blocking: 45/40
WR Catching: 40/45
RB Ability: 55/75
Run Blocking: 40/50
Pass Coverage: 60/60
Interception: 30/30
Rush Defense: 45/55
Tackling: 50/50