I played Madden 10 for the first time since June (season seven of dynasty mode). It was a decent game as my Raiders thumped the Manningless Colts (retired last season). The game felt and looked a lot different from the 11 demo experience. Immediately following the game I put on the demo (all-pro on SLOW speed). I didn't appreciate how different this Madden plays and feels as compared to 10... and 10 is my second favourite Madden (05 is #1). The obvious differences that come to mind are:

Gameplay AND Gameflow are huge game changers IMO
Visuals are stunning
Player models look improved (though #'s are smaller)
Far better cut scenes
Far better intros

However, by far the biggest difference is LOCOMOTION with the RUN GAME!!! As compared to 11, running the ball on Madden 10 is absolutely brutal... the animations look terrible, you have minimal control of movement/direction, etc. I am truly surprised how different the two games feel and I am seriously considering changing my mind and picking up 11... I don't know if I can play 10 again after my comparison of the two titles....???...