Quote Originally Posted by SmoothPancakes View Post
finished up Hole in the Wall in Vault 81, as well as just plain finished up every and any mission in Vault 81.
Spoiler: show

So I am assuming you did not keep the vaccine? Did you or a companion get bit by one of the diseased mole rats? If so check the player status page. Leaves you with -10 hp that can't be cured. It's like losing a level, so not a big deal but annoying nonetheless.