The 4-2-5 is best suited for pass heavy offenses in NCAA 14. The biggest weaknesses are the favorable matchups for slot recievers versus the two Linebackers. I use traditional Linebackers in the role, but use them mostly in blitz or zone support. I use three plays including cover 1 (SS & LB Zone/ everyone else Man); Cover 2 (Man w/ SS & FS Zone), and LB Blitz (Man w/ LB Blitzing). This stops running up the middle. If a team is using zone read option with multiple pitch options hot route LB's to read the QB while attempting to push through with a defensive lineman.

4-2-5 is the hardest defense to break with heavy man coverage and speed breaking up running attempts. Quick passes to slot recievers and slam runs are the best way to defeat this defense as long as you are able to read which style they are using to defeat you. I hope this helps.