Few things while I'm thinking of them:
Related to steelerfan's ... sometimes when the CPU (haven't had it against a user, but I suppose it's possible) runs a no-huddle after the cut scene ... what actually happens is that you're taken back to the standard Playcall screen. You call a play, but then the No-Huddle playcall screen pops up, and you have to choose your play again. Furthermore, after choosing your play, no button works. You might be able to pause (I don't recall if I've tried), but you can't switch players, call hot routes, or do Run/Pass Commit, until the CPU team snaps the ball.
When you're choosing an opposing player to focus on, as a defense, you're shown the receivers as if it follows your own control scheme (noticeable only if you've customized the Receiver 1 - Receiver 5 controls). Last year I noted this because if used the default control scheme, even if you'd customized it. However, this year is shows you your custom scheme ... but you have to use the default scheme. The buttons you choose are tied into the original scheme, regardless of what's displayed about the receiver. This is both a good and bad thing. You can have L2 as a receiver button, but this can't be used with the Defensive Key feature, because you're holding down L2 at the time. Either need to rethink this or return to the default control scheme display for opponents.
Recruit pitch swaying + visit bug as detailed here.
On Ace Bunch Base, there's a toss play to the left (away from the Bunch) with auto-motion. However, the split-end (WR on left) does not make a move to block until a second or two into the play. By then, the man he is supposed to block has, often, already made a play on the ball carrier. It's essentially a broken play.