Yeah I think the Shane and Lori thing may die down now if Carl dies. Or even if he doesn't, I think that keeps Shane with the group now. Part of me thinks that Carl somehow will survive it. I didn't think anything was going to happen to the deer, I thought in the end he would dart off at the last minute, and lead them to Sophia. So that definitely shocked the hell out of me when that shot rang out.
I thought T-Dog was a dead man when his arm was sliced open, but Daryl saved his ass. Daryl also was the one who could be see the trail to try to find Sophia. Plus his crossbow skills, he's pretty badass, so I have a feeling he's dying this year :D
My other guess is Andrea goes nuts when she gets her gun back, and ends up killing someone...probably Glenn.